Adyasa Barik, Rajesh Pandiyan, Malathi Manthiram and Balasubramanian Vellaisamy* Pages 1 - 19 ( 19 )
In recent years, over use of antibiotics has been raising its head to a serious problem all around the world as pathogens become drug resistant and create challenges to the medical field. This failure of most potent antibiotics that kill pathogens increases the thirst for research to look further way of killing pathogens. It has been led to the findings of antimicrobial peptide which is the most potent peptide to destroy pathogens. This review gives special emphasis to the usage of marine bacteria and other microorganisms for antimicrobial peptide (AMP) which are eco friendly as well as a developing class of natural and synthetic peptides with a wide spectrum of targets to pathogenic microbes. Consequently, a significant attention has been paid mainly to (i) the structure and types of anti microbial peptides and (ii) mode of action and mechanism of antimicrobial peptide resistance to pathogens. In addition to this, the designing of AMPs has been analysed thoroughly for reducing toxicity and developing better potent AMP. It has been done by the modified unnatural amino acids by amidation to target the control of biofilm and persister cell.
antimicrobial peptides, biofilm, marine microorganisms, marine bacteria, AMP resistance, amino acids.
Eco-Microbiology Laboratory Department of Microbiology, Alagappa University, Science Campus, Karaikudi-630 003, Tamil Nadu, Department of Biochemistry, Karpagam Academy of Higher Education, Karpagam University Coimbatore-641021. Tamil Nadu, Department of Physics, Seethalakshmi Achi College for Women, Pallatur-630107, Karaikudi. Tamil Nadu, Eco-Microbiology Laboratory Department of Microbiology, Alagappa University, Science Campus, Karaikudi-630 003, Tamil Nadu