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Hypolipidemic and Antioxidant Activities of Corrigiola telephiifolia in Diabetic Rats

[ Vol. 17 , Issue. 1 ]

Author(s):

Morad Hebi and Mohamed Eddouks*   Pages 47 - 51 ( 5 )

Abstract:


Objective: The evaluation of the hypolipidemic and antioxidant activities of the aerial parts aqueous extract of Corrigiola telephiifolia (APAE of C. telephiifolia) in normal and streptozotocin (STZ)-induced diabetic rats.

Methods: The effects of oral administration of APAE of C. telephiifolia (5 mg/kg) on the lipid profile as well as the in vitro antioxidant activity of this aqueous extract have been determined.

Results: APAE of C. telephiifolia (5 mg/kg) reduced significantly (p<0.001) the plasma total cholesterol levels in diabetic rats. In contrast, no significant increase in plasma triglyceride levels in normal and in STZ-induced diabetic rats was observed. On the other hand, APAE of C. telephiifolia showed an antioxidant activity.

Conclusion: The APAE of C. telephiifolia exhibits an antioxidant, cholesterol and body weightlowering activities in diabetic rats.

Keywords:

Antioxidant activities, Corrigiola telephiifolia, flavonoids, streptozotocin, total cholesterol, triglycerides.

Affiliation:

Faculty of Sciences and Techniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, 52000, Errachidia, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, 52000, Errachidia

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