Mohammed Ajebli and Mohamed Eddouks* Pages 28 - 39 ( 12 )
Background and objective: Warionia saharae Benth & Coss, is a medicinal plant used for its antidiabetic properties in Morocco. This study was designed to examine the effect of the flavonoid-enriched extract (FEE) obtained from Warionia saharae (W. saharae) on glucose and lipid metabolism in normal and streptozotocin(STZ)-induced diabetic rats.
Methods: Acute (6 h) and sub-chronic (15 days) oral administration of FEE (10 mg/kg) were used to assess the glucose and lipid lowering activity in normal and diabetic rats. Furthermore, glucose test tolerance, liver histopathological examination and in vitro antioxidant activity of FEE were carried out in this study.
Results: Results indicated that FEE was able to exert antihyperglycemic activity. Additionally, FEE improved histopathological status of liver and pancreas in diabetic rats and possessed antioxidant activity.
Conclusion: In conclusion, the present investigation revealed that FEE had potent antidiabetic effect in diabetic rats.
Antioxidant, diabetes, flavonoid-enriched extract, histopathology, lipid profile, Warionia saharae.
Team of Physiology and Endocrine Pharmacology, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Team of Physiology and Endocrine Pharmacology, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000