Submit Manuscript  

Article Details


Association between Apo B Levels in Mothers and in their Pre-school Age Offspring

[ Vol. 15 , Issue. 1 ]

Author(s):

Valeria Hirschler*, Maximiliano Martin, Karen Oestreicher, Claudia Molinari, Laura Boero, Walter Tetzlaff and Fernando Brites   Pages 62 - 68 ( 7 )

Abstract:


Objective: The study aims to determine the association between apo B levels in mothers and their pre-school offspring.

Methods: Anthropometric measurement (e.g. BMI), lipids, lipoproteins, and apolipoproteins (e.g. apo B) levels in mothers and their children were obtained in November 2015 in Buenos Aires.

Results: Eighty-four children (42M) aged 5.3±1.6 years and their mothers aged 33.8±7.2 years were examined. The prevalence of overweight was 39.2 % (33) in mothers and 22.6 % (19) in children, and the prevalence of obesity was 38.1% (32) in mothers and 10.7% (9) in children. Multiple linear regression analysis showed that maternal apo B levels were associated with apo B levels in their offspring, adjusted for confounding variables (Beta=0.29; p=0.03; R2=0.25). Furthermore, offspring born to mothers with high apo B levels were six times likelier to have high apo B levels (OR), 5.7; (95% CI 1.3-25.5).

Conclusion: This study suggests that maternal apo B levels were significantly associated with apo B concentration in their pre-school age children.

Keywords:

Cardiovascular disease, dyslipidemia, apo B, pre-school children, mothers, BMI.

Affiliation:

University of Buenos Aires, Maipu 812, 5M, Buenos Aires (1006), Laboratory of Lipids and Atherosclerosis, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry, INFIBIOC, University of Buenos Aires, CONICET, Buenos Aires, University of Buenos Aires, Buenos Aires, University of Buenos Aires, Buenos Aires, Laboratory of Lipids and Atherosclerosis, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry, INFIBIOC, University of Buenos Aires, CONICET, Buenos Aires, Laboratory of Lipids and Atherosclerosis, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry, INFIBIOC, University of Buenos Aires, CONICET, Buenos Aires, Laboratory of Lipids and Atherosclerosis, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry, INFIBIOC, University of Buenos Aires, CONICET, Buenos Aires

Graphical Abstract:



Read Full-Text article